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Dipyanone is a synthetic compound that belongs to the class of anthraquinone derivatives. It was first synthesized in 1959 by researchers at the pharmaceutical companybdoz. Its chemical structure consists of a planar aromatic system with an anthracene ring fused to a phenanthrene ring.

Dipyanone Structure

It’s primarily known for its anticancer activity, which is mediated through its ability to inhibit the enzyme dihydrofolate reductase (DHFR). This enzyme plays a crucial role in the folate metabolic pathway, which is essential for the replication and growth of cancer cells. By inhibiting DHFR, dipyanone disrupts the folate-dependent enzymes, leading to the inhibition of DNA and protein synthesis in cancer cells.

Folate Metabolic Pathway

In addition to its anticancer activity, dipyanone also shows promise for a variety of other therapeutic applications. It has been investigated as a potential treatment for autoimmune diseases, such as rheumatoid arthritis and lupus erythematosus. Dipyanone has also been evaluated as a topical agent for the treatment of skin conditions, such as psoriasis and eczema.

The administration of dipyanone typically involves oral administration, either in the form of tablets or capsules. The dosage and duration of treatment depend on the patient’s specific condition and response to the medication. However, it is important to note that they has certain limitations and side effects. It can cause gastrointestinal discomfort, such as nausea, vomiting, and diarrhea, and may also affect bone marrow function, leading to a decrease in the production of blood cells.

                                           Overall, dipyanone is a synthetic compound that has demonstrated anticancer properties and potential therapeutic applications. Its ability to inhibit dihydrofolate reductase makes it an attractive target for drug development, and ongoing research continues to unravel its mechanisms of action and potential clinical applications.

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10 Grams, 25 Grams, 50 Grams, 100 Grams, 250 Grams, 500 Grams, 1KG


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